Streetwise George and his big, childlike friend Lennie are drifters, searching for work in the fields and valleys of California. They have nothing except the clothes on their back, and a hope that one day theyll find a place of their own and live the American dream. But dreams come at a price. Gentle giant Lennie doesnt know his own strength, and when they find work at a ranch he gets into trouble with the bosss daughter-in-law. Trouble so bad that even his protector George may not be able to save him.