Bioinformatics and Functional Genomics

Bioinformatics and Functional Genomics


Yazar Jonathan Pevsner
Yayınevi Wiley-Blackwell
ISBN 9780470085851
Baskı yılı 2009
Sayfa sayısı 984
Ağırlık 1.75 kg
Edisyon 2
Stok durumu Tükendi   

The bestselling introduction to bioinformatics and functional genomics-now in an updated edition Widely received in its previous edition, Bioinformatics and Functional Genomics offers the most broad-based introduction to this explosive new discipline. Now in a thoroughly updated and expanded Second Edition, it continues to be the go-to source for students and professionals involved in biomedical research. This edition provides up-to-the-minute coverage of the fields of bioinformatics and genomics. Features new to this edition include: Several fundamentally important proteins, such as globins, histones, insulin, and albumins, are included to better show how to apply bioinformatics tools to basic biological questions. A completely updated companion web site , which will be updated as new information becomes available - visit www.wiley.com/go/pevsnerbioinformatics Descriptions of genome sequencing projects spanning the tree of life. A stronger focus on how bioinformatics tools are used to understand human disease. The book is complemented by lavish illustrations and more than 500 figures and tables-fifty of which are entirely new to this edition. Each chapter includes a Problem Set, Pitfalls, Boxes explaining key techniques and mathematics/statistics principles, Summary, Recommended Reading, and a list of freely available software. Readers may visit a related Web page for supplemental information at www.wiley.com/go/pevsnerbioinformatics. Bioinformatics and Functional Genomics, Second Edition serves as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It is also an indispensable resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases. Praise for the first edition: "...ideal both for biologists who want to master the application of bioinformatics to real-world problems and for computer scientists who need to understand the biological questions that motivate algorithms." Quarterly Review of Biology "...an excellent textbook for graduate students and upper level undergraduate students. " Annals of Biomedical Engineering "...highly recommended for academic and medical libraries, and for researchers as an introduction and reference..." E-Streams
1 Introduction 3
2 Access to sequence data and literature information 13
3 Pairwise sequence alignment 47
4 Basic local alignment search tool (BLAST) 101
5 Advanced database searching 141
6 Multiple sequence alignment 179
7 Molecule phylogeny and evolution 215
8 Bioinformatic approaches to ribonucleic acid (RNA) 279
9 Gene expression : microarray data analysis 331
10 Protein analysis and proteomics 379
11 Protein structure 421
12 Functional genomics 461
13 Completed genomes 517
14 Completed genomes : viruses 567
15 Completed genomes : bacteria and archaea 597
16 The eukaryotic chromosome 639
17 Eukaryotic genomes : fungi 697
18 Eukaryotic genomes : from parasites to primates 729
19 Human genome 791
20 Human disease 839
Glossary 891
Answers to self-test quizzes 909
Author index 911
Subject index 913